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| Coptis; conjunctivitis | |
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| Tweet Topic Started: Nov 9 2014, 03:07 PM (439 Views) | |
| yass | Nov 9 2014, 03:07 PM Post #1 |
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I can't make up my mind whether to start a topic covering conjunctivitis or coptis. Coptis does more and there are other natural treatments for conjunctivitis. I think I'll make notes about coptis specially noting that it is a treatment for conjunctivitis. --------------------------------------------------------------------------------------- Uses described in pharmacopoeias and in traditional systems of medicine To manage bacterial diarrhoeas (1, 4). The drug is also used in the treatment of acute conjunctivitis, gastroenteritis, boils, and cutaneous and visceral leishmaniasis ("oriental sore") (1, 4, 13, 14). Uses described in folk medicine, not supported by experimental or clinical data Treatment of arthritis, burns, diabetes, dysmenorrhoea, toothache, malaria, gout, and renal disease (13). Read more: http://apps.who.int/medicinedocs/en/d/Js2200e/13.html |
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| yass | Nov 9 2014, 03:49 PM Post #2 |
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Experimental pharmacology Numerous reports support the antimicrobial activity of Rhizoma Coptidis. In vitro studies have shown that the crude drug and its active constituent, berberine, have a similar spectrum of antibacterial action (3, 15). Both inhibit the in vitro growth of staphylococci, streptococci, pneumococci, Vibrio cholerae, Bacillus anthracis, and Bacillus dysenteriae, but they do not inhibit Escherichia coli, Proteus vulgaris, Salmonella typhi, S. paratyphi, Pseudomonas aeruginosa, and Shigella sonnei (3). Berberine was also active in vitro against Entamoeba histolytica, Giardia lamblia, and Trichomonas vaginalis (16). In vitro studies have demonstrated that V. cholerae can grow in a medium containing berberine, but it fails to produce toxins (17). It has been hypothesized that the antidysenteric activity of berberine is due to local effects on the intestinal tract and not due to its bactericidal activity. The mechanism by which berberine exerts its antidiarrhoeal effects is thought to be activation of α2-adrenoceptors and inhibition of cyclic AMP accumulation (18), which in turn decrease intestinal motility (19). However, in vitro studies of the drug on guineapig ileum contractility have demonstrated that berberine (≥1µmol/l) inhibits acetylcholinesterase, which decreases the breakdown of acetylcholine and increases the contractility of the ileum (20). This study suggests that the antidiarrhoeal activity of berberine may be due to its antisecretory (21) as well as its antimicrobial actions (20). Berberine inhibits in vivo and in vitro intestinal secretions induced by cholera toxin (22–24). In addition, berberine reduces intestinal secretion induced by the heat-labile toxin of Escherichia coli in rabbit ileal loop by 70% and it markedly inhibits the secretory response of the heatstable toxin of E. coli in rats (25, 26). --- ... A randomized controlled trial of 165 patients utilized a 400mg single-bolus dose of berberine sulfate for enterotoxigenic Escherichia coli-induced diarrhoea and either 400 mg as a single oral dose or 1200mg of berberine sulfate (400 mg every 8 hours) for the treatment of cholera (33). Berberine significantly reduced stool volume during enterotoxigenic E. coli (ETEC) diarrhoea regardless of strain and had a slight antisecretory activity in patients with cholera. No adverse effects were observed in the patients receiving berberine. The results of this study indicated that berberine was an effective and safe antisecretory drug for ETEC diarrhoea, but that it had only a modest antisecretory effect in cholera patients, where the activity of tetracycline alone was superior (33). http://apps.who.int/medicinedocs/en/d/Js2200e/13.html |
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8:43 AM Jul 13