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Cytokines; for reference
Topic Started: Nov 2 2014, 03:44 AM (308 Views)
yass
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Excerpt:

In July of 2001, JAMA published a study on chronic inflammation and the risk of diabetes. Another test they used, besides the CRP, was an inflammatory marker test, the IL-6. The study concluded that your chances of developing type two diabetes are easily predicted by the outcome of the CRP and IL-6 tests together. The ultimate test would be the Inflammatory Cytokine Profile consisting of the two mentioned plus TNF (tumor necrosis factor), interleukins -1 beta and 8.

What is at stake?

Depression, asthma, pancreatitis, Parkinson's, lupus, anemia, kidney failure, psoriasis, and fibrosis might just be the start. All of these diseases have a suspected root cause of chronic inflammation.

From Life Extension Vitamins, we learned that seemingly unrelated illnesses “often exhibit excess levels of pro-inflammatory markers:

Allergy — Inflammatory cytokines induce autoimmune reactions
Alzheimer's — Chronic inflammation destroys brain cells
Anemia — Inflammatory cytokines attack erythropoietin production
Aortic valve stenosis — Chronic inflammation damages heart valves
Arthritis — Inflammatory cytokines destroy joint cartilage and synovial fluid
Cancer — Chronic inflammation causes many cancers
Congestive heart failure — Chronic inflammation contributes to heart muscle wasting
Fibromyalgia — Inflammatory cytokines are elevated
Fibrosis — Inflammatory cytokines attack traumatized tissue
Heart attack — Chronic inflammation contributes to coronary atherosclerosis
Kidney failure — Inflammatory cytokines restrict circulation and damage nephrons
Lupus — Inflammatory cytokines induce an autoimmune attack
Pancreatitis — Inflammatory cytokines induce pancreatic cell injury
Psoriasis — Inflammatory cytokines induce dermatitis
Stroke — Chronic inflammation promoted thromboembolic events
Surgical complications — Inflammatory cytokines prevent healing

Lets take a closer look at some diseases and their inflammatory connection.

Cancer: in an article entitled “Chronic Inflammation and Cancer,” by Emily Shacter, PhD published in Oncology, she sums up her findings thus:

http://www.mnwelldir.org/docs/terrain/chronic_inflammation.htm
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yass
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Immunological Factors

Immunological factors have been linked to the development of endometriosis and endometriosis related infertility. In early endometriosis (stage 1 & 2) there are elevated levels of inflammatory mediators. Studies have shown elevated levels of cytokines, lymphocytes, and macrophages in the peritoneal fluid of women with early stage endometriosis.

Over time the immune system function appears to alter and may increase the number of peritoneal macrophages, decreased T-cell activity and natural killer cells (NK), increased antibodies and altered cytokine network function. Overall this creates depressed immune function and poor inflammatory response. This may allow endometriotic tissues to implant elsewhere in the body more easily. This may also be why women with endometriosis have more pain, inflammation and are more susceptible to recurrent infections, especially yeast infections.

http://natural-fertility-info.com/endometriosis
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yass
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Cinnamomum verum (bark): Warm and balancing, sweet and spicy inner bark of a beautiful tree. True cinnamon, a spice once more valuable than gold, has multiple health benefits. Rich in calcium, magnesium and manganese, numerous studies have shown that cinnamon can regulate blood sugar levels, making it a great choice for diabetics and hypoglycemics alike, or anyone who wants stable energy levels and moods. Cinnamon contains natural anti-infectious compounds, shown to be effective again ulcer-causing H. pylori bacteria and other pathogens. It has also been shown to reduce LDL cholesterol levels, the harmful cholesterol, thereby helping to reduce the risk of cardiovascular disease. Other studies have shown that cinnamon is pain-relieving, reducing cytokines linked to arthritic pain and may reduce the proliferation of cancer cells, holding promise for cancer prevention and sufferers of the disease. Taste is not the only reason to love true cinnamon! Energetics: Warm to hot, sweet.

http://wildsageteas.com/tonic-herbals/key-herbs/


*I read recently that you should buy whole cinnamon sticks and grind it yourself so you can know it is cinnamon, because most of what they pass off as cinnamon these days is cassia.
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yass
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Coptis

Very interesting herb (value!)

http://www.herbs2000.com/herbs/herbs_coptis.htm

Be sure to read: Side effects and cautions


http://www.herbs2000.com/herbs/herbs_coptis.htm

Coptis inhibits inflammatory cytokines:

Quote:
 
Based on published scientific and clinical research, Coptis:

Reduces nitric oxide generation and expression of inducible nitric oxide synthase;*
Blocks NF kappa B dependent pathways;*
Inhibits proinflammatory cytokines such as TNF-alpha and IL-1 beta;*
Reduces high blood pressure;*
Lowers blood sugar and cholesterol;*
Decreases oxidative stress;*
Increases blood flow to the extremities.*

http://wwwadb.org/anti-inflammatory-herb-coptis

The distinct effect of IBS-20 on LPS-stimulated cytokine expression suggests that the herbs may influence multiple sites/pathways of TLR-4 intracellular signaling to inhibit the LPS-induced pro-inflammatory cytokine production, although more details remain to be fully understood.
http://www.hindawi.com/journals/ecam/2012/491496/


Misc sources:

http://www.ncbi.nlm.nih.gov/pubmed/23871807
http://www.ncbi.nlm.nih.gov/pubmed/20546869
http://www.itmonline.org/articles/scute/scute.htm
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